Hydroxychloroquine Is Being Studied As A Way To Treat Coronavirus

12 hours ago
Originally published on April 8, 2020 11:58 am
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All right. Continuing now our coverage of the virus. There is no confirmed treatment for COVID-19, but President Trump has repeatedly said that there are drugs that could be effective. One of them is called hydroxychloroquine. It's used to treat malaria. It's often prescribed to people who have lupus or rheumatoid arthritis. And while it's not yet clear whether the drug will be useful for COVID-19, President Trump is urging people to consider using it now.


PRESIDENT DONALD TRUMP: And some people say, let's go to a laboratory. Let's test it for a couple of years, and then - no, I got - we got people dying in this country and all over the world right now, not in a couple of years. They're dying - as we speak, there are people dying.

KING: Katherine Seley-Radtke is a medicinal chemist at the University of Maryland, Baltimore County. She specializes in antiviral drug research, including coronaviruses. And she's with me now on Skype. Good morning, Katherine.


KING: What do we know about using hydroxychloroquine as a treatment for COVID-19?

SELEY-RADTKE: Well, hydroxychloroquine has been shown to have no effect, actually, on reducing viral load, so it doesn't cure the virus. How it works tends to be in terms of the cytokine storm or the inflammatory response that our body starts in response to getting the virus.

And in fact, a number of years ago, after the first two coronaviruses came out - the SARS and then the MERS strain of coronavirus - there were animal studies that showed that while the initial testing in the test tube or in vitro testing showed some promise, the actual animal testing showed no efficacy whatsoever in terms of reducing the viral replication.

KING: OK. What further research do you think is needed at this point to say this drug either works or it doesn't or it works to some extent? And how long does it - is it going to take?

SELEY-RADTKE: So as you may or may not be aware, there have been a couple very small trials that - from France and another from China that were reported in the last couple weeks. However, those results were very inconclusive, and in fact, one of the papers from France has now been disparaged by the journal itself. However, there are a number of clinical trials that are starting or have already started recently in the United States and other countries to really look at how this drug works and whether or not it's being useful.

Part of the problem is we have a lot of anecdotal information that many people are relying on rather than relying on the science. And we really need to have these proper clinical trials with proper controls so that we can find out whether or not this is working at all. And many of the people who have taken this have said they don't know if they - if it helped them or not.

KING: They don't know if it helped them or not. OK. How long would it take for a study to be conclusive? And how many people would need to be part of that study? When we talk about clinical trials, are we talking about a couple dozen, a couple thousand?

SELEY-RADTKE: Well, obviously, the more, the better. And I think a number of the trials that are starting are multicenter trials that are being run by the National Institutes of Health, and I think these will encompass hundreds, if not thousands of patients and that will have either no underlying conditions or, as you reported just a minute ago, many underlying conditions, such as diabetes or asthma.

And I think the other aspect of this, too, is there are - we all deal with drugs differently. And so it's important to get sort of a cross section of the population, and some of these early studies were only done on a few people. And in one case, it was very - only people with mild symptoms, and they didn't have any underlying conditions, where in another one they were showing symptoms that were quite serious.

KING: OK. So there is still a lot, it sounds like, we don't know. Katherine Seley-Radtke is the incoming president of the International Society for Antiviral Research. Katherine, thanks so much for joining us this morning.

SELEY-RADTKE: No problem. Transcript provided by NPR, Copyright NPR.